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HRID374628

反应详情

EQUATION

反应方程式

HRID 374628 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccc(S(=O)(=O)Cl)cc1
HCID7397

p-Toluenesulfonyl chloride

C7H7ClO2S

结构：Nc1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1F
HCID67657

2-Amino-2'-fluoro-5-nitrobenzophenone

C13H9FN2O3

PRODUCTS

生成物

1
结构：Cc1ccc(S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2C(=O)c2ccccc2F)cc1
HCID3023542

N-(2-(o-Fluorobenzoyl)-4-nitrophenyl)-p-toluenesulphonamide

C20H15FN2O5S

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

A mixture containing 10 g of 2-amino-5-nitro-2'-fluorobenzophenone and 7.5 g of tosyl chloride is refluxed in 50 ml of pyridine for 24 hours. The solvent is evaporated off to dryness, water and ethyl acetate are added, an insoluble material is filtered off and the organic phase is washed with a dilute solution of hydrochloric acid, water and an aqueous solution of sodium chloride and then dried over magnesium sulfate and evaporated. The residue is chromatographed on silica and the expected product is eluted with DCM.

WORKUP

后处理

  1. customThe solvent is evaporated off to dryness, water and ethyl acetate
  2. additionare added
  3. filtrationan insoluble material is filtered off
  4. washthe organic phase is washed with a dilute solution of hydrochloric acid, water
  5. dry with materialan aqueous solution of sodium chloride and then dried over magnesium sulfate
  6. customevaporated
  7. customThe residue is chromatographed on silica
  8. washthe expected product is eluted with DCM