反应详情

5.6 g of 2-amino-2',5-dichlorobenzophenone and 5 g of 3,4-dimethoxyphenylsulfonyl chloride are heated in pyridine overnight at 100° C. The pyridine is evaporated off to dryness, water and ethyl acetate containing a small amount of DCM are added and the mixture is extracted. After washing several times with water and drying over sodium sulfate, the extract is evaporated under vacuum and 7.7 g of the expected product are recrystallized from a DCM/AcOEt mixture.

1. customThe pyridine is evaporated off to dryness, water and ethyl acetate containing a small amount of DCM
2. additionare added
3. extractionthe mixture is extracted
4. washAfter washing several times with water
5. dry with materialdrying over sodium sulfate
6. customthe extract is evaporated under vacuum and 7.7 g of the expected product
7. customare recrystallized from a DCM/AcOEt mixture