Methyl iodide → HCID 18996960, compound

HRID 374662Notes

Reaction equation

HRID 374662 reaction equation
[OH:1][C:2]1[C:15]2[C:6](=[C:7]([F:20])[C:8]3[C:13]([C:14]=2[O:16][CH3:17])=[CH:12][C:11]([O:18][CH3:19])=[CH:10][CH:9]=3)[CH:5]=[C:4]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:3]=1.[C:26](=O)([O-])[O-].[K+].[K+].IC>C(#N)C>[F:20][C:7]1[C:8]2[C:13]([C:14]([O:16][CH3:17])=[C:15]3[C:6]=1[CH:5]=[C:4]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:3]=[C:2]3[O:1][CH3:26])=[CH:12][C:11]([O:18][CH3:19])=[CH:10][CH:9]=2

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 18997015HCID 18997015, compound

Product 1

HCID 18996960HCID 18996960, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Ethyl 4-hydroxy-6,10-dimethoxy-9-fluoroanthracene-2-carboxylate (4 g) was dissolved in acetonitrile. Potassium carbonate (2.5 g) and iodomethane (3 g) were added. The mixture was heated under reflux with vigorous stirring under nitrogen for 2 hours. The solution was filtered to remove solids and washed with water. The organic phase was washed, dried (MgSO4), filtered and concentrated to give the above compound as a yellow solid.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux
  3. filtrationThe solution was filtered
  4. customto remove solids
  5. washwashed with water
  6. washThe organic phase was washed
  7. dry with materialdried (MgSO4)
  8. filtrationfiltered
  9. concentrationconcentrated

Sources & evidence

ORD record
ord-5e0b0e92afa14494a9ec29427f6503cf
Source dataset
uspto-grants-1996_01
Patent number
US05480873

Reaction notes

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