Hydrochloric Acid → HCID 17846772, compound

HRID 374693Notes

Reaction equation

HRID 374693 reaction equation
C(OC([N:8]1[CH:12]([CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:11]([CH:20]([OH:24])[CH2:21][S:22][CH3:23])[O:10]C1(C)C)=O)(C)(C)C.[ClH:27]>O1CCOCC1>[ClH:27].[NH2:8][CH:12]([CH2:13][CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1)[CH:11]([OH:10])[CH:20]([OH:24])[CH2:21][S:22][CH3:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53712781HCID 53712781, compound

Product 1

HCID 17846772HCID 17846772, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

29.4 mg of (4S,5R or S)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-5-[(1RS)-1-hydroxy-2-methylthioethyl]oxazolidine was dissolved in 0.3 ml of dioxane, and 0.42 ml of a dioxane solution of 3.6M hydrogen chloride was added thereto. From the reaction solution, the solvent was distilled off under reduced pressure to obtain 22.5 mg of (2RS,3R or S,4S)-4-amino-5-cyclohexyl-1-methylthio-2,3-pentanediol hydrochloride as colorless oily substance.

Workup

  1. distillationFrom the reaction solution, the solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-3dccf1ccd94b4df58d4b909cd48cfd6c
Source dataset
uspto-grants-1996_01
Patent number
US05481036

Reaction notes

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