HCID 19935602, compound → 3-Amino-4,5-diethoxycarbonyl-6-dimethylamino-2-phenylpyridine

HRID 37473Notes

Reaction equation

HRID 37473 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([N:26]([CH3:28])[CH3:27])=[N:8][C:9]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:10]([N+:17]([O-])=O)[C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[O:5])[CH3:2]>C(OCC)(=O)C.[Pd]>[NH2:17][C:10]1[C:9]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[N:8][C:7]([N:26]([CH3:28])[CH3:27])=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13]

Participants

4

Reactant 1

HCID 19935602HCID 19935602, compound

Product 1

HCID 152897093-Amino-4,5-diethoxycarbonyl-6-dimethylamino-2-phenylpyridine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

In 2 ml of ethyl acetate Was dissolved 52 mg of 3,4-diethoxycarbonyl-2-dimethylamino-5-nitro-6-phenylpyridine, whereto 50 mg of 10% Pd-C (50% wet) was added. Catalytic reduction reaction was conducted for 5.5 hours. After the catalyst was removed, the solvent was distilled off and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane 1:2).

Workup

  1. additionwas added
  2. customCatalytic reduction reaction
  3. customAfter the catalyst was removed
  4. distillationthe solvent was distilled off
  5. customthe residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane 1:2)

Sources & evidence

ORD record
ord-bb8a3d4bd4d54bd7a629646d494af9ba
Source dataset
uspto-grants-1995_05
Patent number
US05420275

Reaction notes

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