反应详情

In 90 ml of 2% hydrochloric acid was dissolved 2.52 g (10 mmol) of 2-amino-3,4-diethoxycarbonyl-6-methylpyridine. A solution of 0.83 g (1.2 eq.) of sodium nitrite dissolved in 3 ml of water was added dropwise to the solution. The mixture was stirred at room temperature for 1 hour and left standing in a refrigerator overnight. The resulting crystals were collected by filtration. The crystals were recrystallized from ethyl acetate to give colorless plates.

1. additionwas added dropwise to the solution
2. waitleft
3. customstanding in a refrigerator overnight
4. filtrationThe resulting crystals were collected by filtration
5. customThe crystals were recrystallized from ethyl acetate
6. customto give colorless plates