HCID 20788751, compound → HCID 20788749, compound

HRID 374750Notes

Reaction equation

HRID 374750 reaction equation
C([O:5][C:6](=[O:27])[C@H:7]([CH3:26])[NH:8][C:9](=[O:25])[CH:10]([O:14][C:15]1[N:20]=[C:19]([O:21][CH3:22])[CH:18]=[C:17]([O:23][CH3:24])[N:16]=1)[CH:11]([CH3:13])[CH3:12])(C)(C)C>FC(F)(F)C(O)=O>[CH3:22][O:21][C:19]1[CH:18]=[C:17]([O:23][CH3:24])[N:16]=[C:15]([O:14][CH:10]([CH:11]([CH3:13])[CH3:12])[C:9]([NH:8][C@H:7]([C:6]([OH:27])=[O:5])[CH3:26])=[O:25])[N:20]=1

Participants

3

Reactant 1

HCID 20788751HCID 20788751, compound

Product 1

HCID 20788749HCID 20788749, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

2 g of N-[2-[(4,6-dimethoxy-pyrimidin-2-yl)oxy]-3-methyl-butyryl]-L-alanine tert-butyl ester (Example 1.023) are added to 20 ml of trifluoroacetic acid. After one hour, the reaction mixture is concentrated by evaporation, taken up in ethyl acetate, washed once with dilute hydrochloric acid, dried over sodium sulfate and again concentrated by evaporation, yielding N-[2-[(4,6-dimethoxy-pyrimidin-2-yl)oxy]-3-methyl-butyryl]-L-alanine as a crystalline product; m.p.: 157°-160° C. (from ethyl acetate).

Workup

  1. concentrationthe reaction mixture is concentrated by evaporation
  2. washwashed once with dilute hydrochloric acid
  3. dry with materialdried over sodium sulfate
  4. concentrationagain concentrated by evaporation

Sources & evidence

ORD record
ord-8720c1d934c34fe7a96de3c8229c3c3c
Source dataset
uspto-grants-1996_01
Patent number
US05482920

Reaction notes

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