Hydrazine hydrate (1:1) → HCID 15289591, compound

HRID 37478Notes

Reaction equation

HRID 37478 reaction equation
[NH2:1][C:2]1[C:3]([CH3:19])=[N:4][C:5](Cl)=[C:6]([C:13](OCC)=[O:14])[C:7]=1[C:8](OCC)=[O:9].O.[NH2:21][NH2:22]>>[NH2:1][C:2]1[C:7]2[C:8](=[O:9])[NH:22][NH:21][C:13](=[O:14])[C:6]=2[CH:5]=[N:4][C:3]=1[CH3:19]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 15289693Diethyl 5-amino-2-chloro-6-methylpyridine-3,4-dicarboxylate

Product 1

HCID 15289591HCID 15289591, compound

Conditions

Temperature
100 °C

Procedure

To 57 mg of 3-amino-6-chloro-4,5-diethoxycarbonyl-2-methylpyridine was added 0.5 ml of hydrazine monohydrate, and the mixture was heated in a stream of nitrogen at 100° C. for 30 minutes. The solvent is distilled off, and the resultant crystals were collected by filtration with ethanol. After water was added to the crystals, the mixture was neutralized with 1N hydrochloric acid.

Workup

  1. distillationThe solvent is distilled off
  2. filtrationthe resultant crystals were collected by filtration with ethanol
  3. additionAfter water was added to the crystals

Sources & evidence

ORD record
ord-23d374163e39458eb369e1c6a6d75ce3
Source dataset
uspto-grants-1995_05
Patent number
US05420275

Reaction notes

Loading…