反应详情

温度

-30 °C

In 8 ml of acetic anhydride was suspended 1.2 g of 3,4-diethoxycarbonyl-6-(4-methoxyphenyl)-2(1H)pyridone. After the mixture was cooled to -30° C. 0 36 ml of fuming nitric acid was added dropwise, followed by stirring for 45 minutes. After water was added, stirring was continued for further 1 hour. The viscous product was collected by filtration, crystallized with diethyl ether and washed.

1. stirringstirring
2. waitwas continued for further 1 hour
3. filtrationThe viscous product was collected by filtration
4. customcrystallized with diethyl ether
5. washwashed