HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 37482Generated: October 28, 2026
Nitric Acid → 3,4-Diethoxycarbonyl-6-(4-methoxyphenyl)-5-nitro-2(1H)pyridone
https://huagongshe.com/reaction/37482
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 3,4-Diethoxycarbonyl-6-(4-methoxyphenyl)-2-pyridone | HCID 19935594 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | 3,4-Diethoxycarbonyl-6-(4-methoxyphenyl)-5-nitro-2(1H)pyridone | HCID 19935614 | — |
Reaction Steps
In 8 ml of acetic anhydride was suspended 1.2 g of 3,4-diethoxycarbonyl-6-(4-methoxyphenyl)-2(1H)pyridone. After the mixture was cooled to -30° C. 0 36 ml of fuming nitric acid was added dropwise, followed by stirring for 45 minutes. After water was added, stirring was continued for further 1 hour. The viscous product was collected by filtration, crystallized with diethyl ether and washed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05420275 |
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| Source dataset | uspto-grants-1995_05 |
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| ORD ID | ord-15d31b3435d449ba88e4a5b2d8d62c85 |
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| Source note | uspto-grants-1995_05 |
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