Sodium Acetate → HCID 178449193, compound

HRID 374830Notes

Reaction equation

HRID 374830 reaction equation
[C:1]([N:3]=[C:4]([NH:26][CH2:27][CH:28]([CH3:30])[CH3:29])[NH:5][C:6]1[CH:7]=[C:8](/[C:12](/[C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)=[CH:13]\[CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])[CH:9]=[CH:10][CH:11]=1)#[N:2].C([O-])(=[O:33])C.[Na+]>Cl>[C:1]([N:3]=[C:4]([NH:26][CH2:27][CH:28]([CH3:30])[CH3:29])[NH:5][C:6]1[CH:7]=[C:8](/[C:12](/[C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)=[CH:13]\[CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])[CH:9]=[CH:10][CH:11]=1)(=[O:33])[NH2:2]

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 178449186HCID 178449186, compound

Product 1

HCID 178449193HCID 178449193, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

1.34 g of 5E-6-(3-(2-cyano-3-(2-methylpropyl)guanidino)phenyl)-6-(3-pyridyl)hex-5-enoic acid are dissolved in 50 ml of 4N hydrochloric acid and stirred for 48 hours at ambient temperature. The solution is adjusted to pH 5-6 by the addition of sodium acetate and extracted with ethyl acetate. The organic extract is evaporated down and the residue is purified over a silica gel column with dichloromethane/ethanol=19:1.

Workup

  1. extractionextracted with ethyl acetate
  2. extractionThe organic extract
  3. customis evaporated down
  4. customthe residue is purified over a silica gel column with dichloromethane/ethanol=19:1

Sources & evidence

ORD record
ord-ee99e1c1e627414ba01fe1ac33767a8b
Source dataset
uspto-grants-1996_01
Patent number
US05482948

Reaction notes

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