Hydrazine hydrate (1:1) → HCID 9861829, compound

HRID 37485Notes

Reaction equation

HRID 37485 reaction equation
[NH2:1][C:2]1[C:3]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)=[N:4][C:5]([Cl:18])=[C:6]([C:13](OCC)=[O:14])[C:7]=1[C:8](OCC)=[O:9].O.[NH2:28][NH2:29]>>[NH2:1][C:2]1[C:7]2[C:8](=[O:9])[NH:29][NH:28][C:13](=[O:14])[C:6]=2[C:5]([Cl:18])=[N:4][C:3]=1[C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 15289694HCID 15289694, compound

Product 1

HCID 9861829HCID 9861829, compound

Conditions

Temperature
100 °C

Procedure

To 210 mg of 3-amino-6-chloro-4,5-diethoxycarbonyl-2-(4-methoxyphenyl)pyridine was added 3 ml of hydrazine monohydrate, and the mixture was heated at 100° C. in a stream of nitrogen for 30 minutes. After solvent was distilled off, the resulting crystals were collected by filtration with ethanol. Water was added to the crystals, and the mixture was neutralized with 1N hydrochloric acid, followed by collection of the crystals by filtration.

Workup

  1. distillationAfter solvent was distilled off
  2. filtrationthe resulting crystals were collected by filtration with ethanol
  3. additionWater was added to the crystals
  4. filtrationfollowed by collection of the crystals by filtration

Sources & evidence

ORD record
ord-5d06f69e1ef642a6812d39fef1df4759
Source dataset
uspto-grants-1995_05
Patent number
US05420275

Reaction notes

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