Benzophenone, 4-amino-3-methyl- → N-(4-Benzoyl-2-bromophenyl)-2-(difluoromethyl)-3,3,-difluoro-2-hydroxypropanamide

HRID 374879Notes

Reaction equation

HRID 374879 reaction equation
[F:1][CH:2]([F:11])[C:3]([CH:8]([F:10])[F:9])([OH:7])[C:4](O)=[O:5].[NH2:12][C:13]1[CH:26]=[CH:25][C:16]([C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:18])=[CH:15][C:14]=1C.NC1C=CC(C(C2C=CC=CC=2)=O)=C([Br:43])C=1>>[C:17]([C:16]1[CH:25]=[CH:26][C:13]([NH:12][C:4](=[O:5])[C:3]([CH:8]([F:10])[F:9])([OH:7])[CH:2]([F:11])[F:1])=[C:14]([Br:43])[CH:15]=1)(=[O:18])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 21052Benzophenone, 4-amino-3-methyl-HCID 222874542,2-Bis-difluoromethyl-2-hydroxyacetic acidHCID 536696854-Amino-2-bromobenzophenone

Product 1

HCID 11662014N-(4-Benzoyl-2-bromophenyl)-2-(difluoromethyl)-3,3,-difluoro-2-hydroxypropanamide

Procedure

Using a procedure similar to that described in Example 1, except replacing the 3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid with 3,3-difluoro-2-difluoromethyl-2-hydroxypropanoic acid and the 4-amino-3-methylbenzophenone with 4-amino-2-bromobenzophenone, the title compound was prepared; mp 128°-132° C. Analysis for C17H12BrF4NO3 : Calculated: C, 47.13; H, 2.79; N, 3.23; Found: C, 56.21; H, 2.95; N, 3.14.

Sources & evidence

ORD record
ord-3d158401891a441a9200cff520c2960c
Source dataset
uspto-grants-1996_01
Patent number
US05482969

Reaction notes

Loading…