HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzophenone, 4-amino-3-methyl- → N-(4-Benzoyl-2-bromophenyl)-2-(difluoromethyl)-3,3,-difluoro-2-hydroxypropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzophenone, 4-amino-3-methyl- | HCID 21052 | — |
| Reactant | 2,2-Bis-difluoromethyl-2-hydroxyacetic acid | HCID 22287454 | — |
| Reactant | 4-Amino-2-bromobenzophenone | HCID 53669685 | — |
| Product | N-(4-Benzoyl-2-bromophenyl)-2-(difluoromethyl)-3,3,-difluoro-2-hydroxypropanamide | HCID 11662014 | — |
Reaction Steps
Using a procedure similar to that described in Example 1, except replacing the 3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid with 3,3-difluoro-2-difluoromethyl-2-hydroxypropanoic acid and the 4-amino-3-methylbenzophenone with 4-amino-2-bromobenzophenone, the title compound was prepared; mp 128°-132° C. Analysis for C17H12BrF4NO3 : Calculated: C, 47.13; H, 2.79; N, 3.23; Found: C, 56.21; H, 2.95; N, 3.14.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05482969 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-3d158401891a441a9200cff520c2960c |
| Source note | uspto-grants-1996_01 |