Acetic Acid → HCID 15289697, compound

HRID 37490Notes

Reaction equation

HRID 37490 reaction equation
[Br:1][C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:6]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:5]([N+:18]([O-])=O)=[C:4]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:3]=1.C(O)(=O)C>C(O)C>[NH2:18][C:5]1[C:4]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[N:3][C:2]([Br:1])=[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:6]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 199356152-Bromo-3,4-diethoxycarbonyl-5-nitro-6-phenylpyridine

Product 1

HCID 15289697HCID 15289697, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

In 25 ml of ethanol was dissolved 550 mg of 2-bromo-3,4-diethoxycarbonyl-5-nitro-6-phenylpyridine, whereto 0.36 g (5 eq.) of reduced iron was added, followed by heating to 60° C. After 1.5 ml (16 eq.) of acetic acid was added dropwise, the mixture was refluxed for 1 hour.

Workup

  1. additionwas added
  2. temperaturethe mixture was refluxed for 1 hour

Sources & evidence

ORD record
ord-98d021ae1c9a43bb964f4d1eb95679d9
Source dataset
uspto-grants-1995_05
Patent number
US05420275

Reaction notes

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