Hydroxyamine hydrochloride → HCID 18654051, compound

HRID 374903Notes

Reaction equation

[CH3:1][O:2][C:3]1([C:9]2[S:13][C:12]([S:14][C:15]3[CH:20]=[CH:19][C:18]([C:21](=O)[CH3:22])=[CH:17][CH:16]=3)=[N:11][CH:10]=2)[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.Cl.[NH2:25][OH:26]>>[CH3:1][O:2][C:3]1([C:9]2[S:13][C:12]([S:14][C:15]3[CH:20]=[CH:19][C:18](/[C:21](=[N:25]/[OH:26])/[CH3:22])=[CH:17][CH:16]=3)=[N:11][CH:10]=2)[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996134HCID 18996134, compound

Product 1

HCID 18654051HCID 18654051, compoundYield 80%

Procedure

Using an analogous procedure to that described in Example 15, 4'-[5-(4-methoxytetrahydropyran-4-yl)thiazol-2-ylthio]acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-[5-(4-methoxytetrahydropyran-4-yl)thiazol-2-ylthio]acetophenone oxime in 80% yield, m.p. 114°-116° C.;

Sources & evidence

ORD record: ord-d09b5a593eef4a488c3e14d0a1eba707
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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