Hydroxyamine hydrochloride → HCID 18654022, compound

HRID 374906Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C@@:18]2([O:25][CH3:26])[CH2:23][CH2:22][O:21][C@@H:20]([CH3:24])[CH2:19]2)[CH:5]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=O)[CH3:16])=[CH:11][CH:10]=2)[CH:7]=1.Cl.[NH2:28][OH:29]>>[F:1][C:2]1[CH:3]=[C:4]([C@@:18]2([O:25][CH3:26])[CH2:23][CH2:22][O:21][C@@H:20]([CH3:24])[CH2:19]2)[CH:5]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12](/[C:15](=[N:28]/[OH:29])/[CH3:16])=[CH:11][CH:10]=2)[CH:7]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 57180041HCID 57180041, compound

Product 1

HCID 18654022HCID 18654022, compoundYield 66%

Procedure

Using an analogous procedure to that described in Example 25, 4'-{5-fluoro-3-[(2S,4R)-4-methoxy-2-methyltetrahydropyran-4-yl]phenylthio]acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-{5-fluoro-3-[(2S,4R)-4-methoxy-2-methyltetrahydropyran-4-yl]phenylthio}acetophenone oxime in 66% yield, m.p. 105° C.;

Sources & evidence

ORD record: ord-a36be96a2ebe478d9769bdc3055a8e4d
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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