Hydroxyamine hydrochloride → HCID 18654036, compound

HRID 374908Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([S:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([C:23]3([O:29][CH3:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[CH:17]=2)[CH:12]=[CH:11][C:10]=1[C:31](=O)[CH3:32])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:35][OH:36]>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([S:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([C:23]3([O:29][CH3:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[CH:17]=2)[CH:12]=[CH:11][C:10]=1/[C:31](=[N:35]/[OH:36])/[CH3:32])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996092HCID 18996092, compound

Product 1

HCID 18654036HCID 18654036, compoundYield 47%

Procedure

Using an analogous procedure to that described in Example 7, 2'-benzyloxy-4'-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]acetophenone was reacted with hydroxylamine hydrochloride to give (E)-2'-benzyloxy-4'-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]acetophenone oxime in 47% yield, m.p. 130°-131° C.;

Sources & evidence

ORD record: ord-ca8e8543335240cfbae3eb5bb0231f29
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

Loading…