Hydroxyamine hydrochloride → HCID 86747993, compound

HRID 374910Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH2:9][C:10]2[CH:19]=[C:18]3[C:13]([C:14](=O)[CH2:15][CH2:16][O:17]3)=[CH:12][CH:11]=2)[CH:5]=[C:4]([C:21]2([O:27][CH3:28])[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[N:3]=1.Cl.[NH2:30][OH:31]>>[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH2:9][C:10]2[CH:19]=[C:18]3[C:13]([C:14](=[N:30][OH:31])[CH2:15][CH2:16][O:17]3)=[CH:12][CH:11]=2)[CH:5]=[C:4]([C:21]2([O:27][CH3:28])[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[N:3]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996268HCID 18996268, compound

Product 1

HCID 86747993HCID 86747993, compoundYield 79%

Procedure

Using an analogous procedure to that described in Example 43, 7-[2-amino-6-(4-methoxytetrahydropyran-4-yl)pyrimidin-4-yloxymethyl]chroman-4-one was reacted with hydroxylamine hydrochloride to give 7-[2-amino-6-(4-methoxytetrahydropyran-4-yl)pyrimidin-4-yloxymethyl]chroman-4-one oxime in 79% yield, m.p. 224°-228° C.;

Sources & evidence

ORD record: ord-ee50d82b983340fd88bf7fc86a3c76cb
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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