Hydroxyamine hydrochloride → HCID 136378409, compound

HRID 374913Notes

Reaction equation

[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]([C:8]1[CH:13]=[CH:12][C:11]([S:14][C:15]2[CH:20]=[C:19]([F:21])[CH:18]=[C:17]([C:22]3([O:28][CH3:29])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[CH:16]=2)=[CH:10][CH:9]=1)=O.Cl.[NH2:31][OH:32]>>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6](=[N:31][OH:32])[C:8]1[CH:13]=[CH:12][C:11]([S:14][C:15]2[CH:20]=[C:19]([F:21])[CH:18]=[C:17]([C:22]3([O:28][CH3:29])[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)[CH:16]=2)=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996235HCID 18996235, compound

Product 1

HCID 136378409HCID 136378409, compoundYield 40%

Procedure

Using an analogous procedure to that described in Example 12, 4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]phenyl 2-thiazolyl ketone was reacted with hydroxylamine hydrochloride to give in turn the geometric isomers of 4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]phenyl 2-thiazolyl ketone oxime:

Sources & evidence

ORD record: ord-71f71e081e62453fb1462ce99cf14938
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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