Hydroxyamine hydrochloride → HCID 86747996, compound

HRID 374915Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C:21]2([O:27][CH3:28])[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[CH:5]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=O)[C:16]([F:19])([F:18])[F:17])=[CH:11][CH:10]=2)[CH:7]=1.Cl.[NH2:30][OH:31]>>[F:1][C:2]1[CH:3]=[C:4]([C:21]2([O:27][CH3:28])[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[CH:5]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=[N:30][OH:31])[C:16]([F:19])([F:18])[F:17])=[CH:11][CH:10]=2)[CH:7]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996281HCID 18996281, compound

Product 1

HCID 86747996HCID 86747996, compoundYield 70%

Procedure

Using an analogous procedure to that described in Example 69, 4'-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-α,α,α-trifluoroacetophenone was reacted with hydroxylamine hydrochloride to give 4'-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-α,α,α-trifluoroacetophenone oxime in 70% yield, m.p. 131°-133° C.;

Sources & evidence

ORD record: ord-7ad040e3bee645f5846e6fd106ad5776
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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