Hydroxyamine hydrochloride → HCID 18654039, compound

HRID 374916Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=O)[CH3:16])=[CH:11][CH:10]=2)[CH:5]=[C:4]([C:18]2([O:24][CH3:25])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[N:3]=1.Cl.[NH2:27][OH:28]>>[NH2:1][C:2]1[N:7]=[C:6]([S:8][C:9]2[CH:10]=[CH:11][C:12](/[C:15](=[N:27]/[OH:28])/[CH3:16])=[CH:13][CH:14]=2)[CH:5]=[C:4]([C:18]2([O:24][CH3:25])[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)[N:3]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996091HCID 18996091, compound

Product 1

HCID 18654039HCID 18654039, compoundYield 75%

Procedure

Using an analogous procedure to that described in Example 43, 4'-[2-amino-6-(4-methoxytetrahydropyran-4-yl)pyrimidin-4-ylthio]acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-[2-amino-6-(4-methoxytetrahydropyran-4-yl)pyrimidin-4-ylthio]acetophenone oxime in 75% yield, m.p. 237°-240° C.;

Sources & evidence

ORD record: ord-14da5975abff4e759341c1df9206656b
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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