Hydroxyamine hydrochloride → HCID 18996065, compound

HRID 374917Notes

Reaction equation

[CH3:1][O:2][C:3]1([C:9]2[CH:10]=[C:11]([S:14][C:15]3[CH:24]=[C:23]4[C:18]([C:19](=O)[CH2:20][CH2:21][O:22]4)=[CH:17][CH:16]=3)[S:12][CH:13]=2)[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.Cl.[NH2:27][OH:28]>>[CH3:1][O:2][C:3]1([C:9]2[CH:10]=[C:11]([S:14][C:15]3[CH:24]=[C:23]4[C:18](/[C:19](=[N:27]/[OH:28])/[CH2:20][CH2:21][O:22]4)=[CH:17][CH:16]=3)[S:12][CH:13]=2)[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996215HCID 18996215, compound

Product 1

HCID 18996065HCID 18996065, compoundYield 82%

Procedure

Using an analogous procedure to that described in Example 7, 7-[4-(4-methoxytetrahydropyran-4-yl)thien-2-ylthio]chroman-4-one was reacted with hydroxylamine hydrochloride to give (E)-7-[4-(4-methoxytetrahydropyran-4-yl)thien-2-ylthio]chroman-4-one oxime in 82% yield, m.p. 137°-138° C.;

Sources & evidence

ORD record: ord-d33a297f73ff4bfd850dae1c1795183e
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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