Hydroxyamine hydrochloride → HCID 86747999, compound

HRID 374919Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C:19]2([O:25][CH3:26])[CH2:23][CH2:22][O:21][CH:20]2[CH3:24])[CH:5]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=O)[CH2:16][CH3:17])=[CH:11][CH:10]=2)[CH:7]=1.Cl.[NH2:28][OH:29]>>[F:1][C:2]1[CH:3]=[C:4]([C:19]2([O:25][CH3:26])[CH2:23][CH2:22][O:21][CH:20]2[CH3:24])[CH:5]=[C:6]([S:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=[N:28][OH:29])[CH2:16][CH3:17])=[CH:11][CH:10]=2)[CH:7]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996156HCID 18996156, compound

Product 1

HCID 86747999HCID 86747999, compoundYield 15%

Procedure

Using an analogous procedure that described in Example 66, 4'-{5-fluoro-3-[(2RS,3SR)-3-methoxy-2-methyltetrahydrofuran-3-yl]phenylthio}propiophenone was reacted with hydroxylamine hydrochloride to give 4'-{5-fluoro-3-[(2RS,3SR)-3-methoxy-2-methyltetrahydrofuran-3-yl]phenylthio}propiophenone oxime in 15% yield, m.p. 113°-114° C.

Sources & evidence

ORD record: ord-bfd05cf1fc7d45c5bba0b3c47eb80edd
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

Loading…