Hydroxyamine hydrochloride → HCID 18996121, compound

HRID 374923Notes

Reaction equation

[CH3:1][O:2][C:3]1([C:9]2[CH:10]=[C:11]([S:14][C:15]3[CH:20]=[CH:19][C:18]([C:21](=O)[CH3:22])=[CH:17][CH:16]=3)[S:12][CH:13]=2)[CH2:7][CH2:6][O:5][CH:4]1[CH3:8].Cl.[NH2:25][OH:26]>>[CH3:1][O:2][C:3]1([C:9]2[CH:10]=[C:11]([S:14][C:15]3[CH:20]=[CH:19][C:18](/[C:21](=[N:25]/[OH:26])/[CH3:22])=[CH:17][CH:16]=3)[S:12][CH:13]=2)[CH2:7][CH2:6][O:5][CH:4]1[CH3:8]

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996229HCID 18996229, compound

Product 1

HCID 18996121HCID 18996121, compoundYield 87%

Procedure

Using an analogous procedure to that described in Example 66, 4'-{4-[(2RS,3SR)-3-methoxy-2-methyltetrahydrofuran-3-yl]thien-2-ylthio}acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-{4-[(2RS,3SR)-3-methoxy-2-methyltetrahydrofuran-3-yl]thien-2-ylthio}acetophenone oxime in 87% yield, m.p. 105°-107° C.

Sources & evidence

ORD record: ord-d6cbb3423a534694ad96063d4e6d48f3
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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