Hydroxyamine hydrochloride → HCID 18996111, compound

HRID 374924Notes

Reaction equation

[CH3:1][O:2][C:3]1([C:9]2[CH:10]=[C:11]([S:14][C:15]3[CH:16]=[C:17]4[C:21](=[CH:22][CH:23]=3)[C:20](=O)[CH2:19][CH2:18]4)[S:12][CH:13]=2)[CH2:7][CH2:6][O:5][CH:4]1[CH3:8].Cl.[NH2:26][OH:27]>>[CH3:1][O:2][C:3]1([C:9]2[CH:10]=[C:11]([S:14][C:15]3[CH:16]=[C:17]4[C:21](=[CH:22][CH:23]=3)/[C:20](=[N:26]/[OH:27])/[CH2:19][CH2:18]4)[S:12][CH:13]=2)[CH2:7][CH2:6][O:5][CH:4]1[CH3:8]

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996109HCID 18996109, compound

Product 1

HCID 18996111HCID 18996111, compoundYield 64%

Procedure

Using an analogous procedure to that described in Example 66, 5-{4-[(2RS,3SR)-3-methoxy-2-methyltetrahydrofuran-3-yl]thien-2-ylthio}indan-1-one was reacted with hydroxylamine hydrochloride to give (E)-5-{4-[(2RS,3SR)-3-methoxy-2-methyltetrahydrofuran-3-yl]thien-2-ylthio}indan-1-one oxime in 64% yield, m.p. 149°-151° C.

Sources & evidence

ORD record: ord-058d9b646c934629a8c5bedb89e34dab
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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