Hydroxyamine hydrochloride → HCID 86748004, compound

HRID 374926Notes

Reaction equation

[CH:1]1([CH:4]2[O:8][C:7]([C:10]3[CH:11]=[C:12]([S:15][C:16]4[CH:21]=[CH:20][C:19]([C:22](=O)[CH3:23])=[CH:18][CH:17]=4)[S:13][CH:14]=3)([CH3:9])[CH2:6][O:5]2)[CH2:3][CH2:2]1.Cl.[NH2:26][OH:27]>>[CH:1]1([CH:4]2[O:8][C:7]([C:10]3[CH:11]=[C:12]([S:15][C:16]4[CH:21]=[CH:20][C:19]([C:22](=[N:26][OH:27])[CH3:23])=[CH:18][CH:17]=4)[S:13][CH:14]=3)([CH3:9])[CH2:6][O:5]2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996106HCID 18996106, compound

Product 1

HCID 86748004HCID 86748004, compoundYield 50%

Procedure

Using an analogous procedure to that described in Example 68, 4'-[4-(2-cyclopropyl-4-methyl-1,3-dioxolan-4-yl)thien-2-ylthio]acetophenone was reacted with hydroxylamine hydrochloride to give 4'-[4-(2-cyclopropyl-4-methyl-1,3-dioxolan-4-yl)thien-2-ylthio]acetophenone oxime in 50% yield as an oil.

Sources & evidence

ORD record: ord-218d57aa32c14181946b42b3a8060b5e
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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