Hydroxyamine hydrochloride → HCID 18996067, compound

HRID 374927Notes

Reaction equation

[CH3:1][C:2]1([CH3:24])[O:6][C:5]([C:8]2[CH:9]=[C:10]([S:13][C:14]3[CH:15]=[C:16]4[C:20](=[CH:21][CH:22]=3)[C:19](=O)[CH2:18][CH2:17]4)[S:11][CH:12]=2)([CH3:7])[CH2:4][O:3]1.Cl.[NH2:26][OH:27]>>[CH3:1][C:2]1([CH3:24])[O:6][C:5]([C:8]2[CH:9]=[C:10]([S:13][C:14]3[CH:15]=[C:16]4[C:20](=[CH:21][CH:22]=3)/[C:19](=[N:26]/[OH:27])/[CH2:18][CH2:17]4)[S:11][CH:12]=2)([CH3:7])[CH2:4][O:3]1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996226HCID 18996226, compound

Product 1

HCID 18996067HCID 18996067, compoundYield 60%

Procedure

Using an analogous procedure to that described in Example 68, 5-[4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)thien-2-ylthio]indan-1-one was reacted with hydroxylamine hydrochloride to give (E)-5-[4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)thien-2-ylthio]indan-1-one oxime in 60% yield as a foam.

Sources & evidence

ORD record: ord-01f8a7a03583467db25b29d3b36b6c7d
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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