Hydroxyamine hydrochloride → HCID 18654041, compound

HRID 374929Notes

Reaction equation

[CH3:1][C:2]1([CH3:24])[O:6][C:5]([C:8]2[CH:9]=[C:10]([S:14][C:15]3[CH:20]=[CH:19][C:18]([C:21](=O)[CH3:22])=[CH:17][CH:16]=3)[CH:11]=[CH:12][CH:13]=2)([CH3:7])[CH2:4][O:3]1.Cl.[NH2:26][OH:27]>>[CH3:1][C:2]1([CH3:24])[O:6][C:5]([C:8]2[CH:9]=[C:10]([S:14][C:15]3[CH:20]=[CH:19][C:18](/[C:21](=[N:26]/[OH:27])/[CH3:22])=[CH:17][CH:16]=3)[CH:11]=[CH:12][CH:13]=2)([CH3:7])[CH2:4][O:3]1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996174HCID 18996174, compound

Product 1

HCID 18654041HCID 18654041, compoundYield 51%

Procedure

Using an analogous procedure to that described in Example 68, 4'-[3-(2,2,4-trimethyl-1,3-dioxolan-4-yl)phenylthio]acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-[3-(2,2,4-trimethyl-1,3-dioxolan-4-yl)phenylthio]acetophenone oxime in 51% yield as a gum.

Sources & evidence

ORD record: ord-fcb180a79c2946f48159584259537fbd
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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