Hydroxyamine hydrochloride → HCID 18996089, compound

HRID 374933Notes

Reaction equation

[CH3:1][O:2][C:3]1([C:9]2[S:10][C:11]([S:14][C:15]3[CH:20]=[CH:19][C:18]([C:21](=O)[CH3:22])=[CH:17][CH:16]=3)=[CH:12][N:13]=2)[CH2:7][CH2:6][O:5][CH:4]1[CH3:8].Cl.[NH2:25][OH:26]>>[CH3:1][O:2][C:3]1([C:9]2[S:10][C:11]([S:14][C:15]3[CH:20]=[CH:19][C:18](/[C:21](=[N:25]/[OH:26])/[CH3:22])=[CH:17][CH:16]=3)=[CH:12][N:13]=2)[CH2:7][CH2:6][O:5][CH:4]1[CH3:8]

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996190HCID 18996190, compound

Product 1

HCID 18996089HCID 18996089, compoundYield 98%

Procedure

Using an analogous procedure to that described in Example 66, 4'-{2-[(2RS,3RS)-3-methoxy-2-methyltetrahydrofuran-3-yl]thiazol-5-ylthio}acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-{2-[(2RS,3RS)-3-methoxy-2-methyltetrahydrofuran-3-yl]thiazol-5-ylthio}acetophenone oxime in 98% yield as a gum.

Sources & evidence

ORD record: ord-71a46a0644a74c9da3db054a9d38e304
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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