Hydroxyamine hydrochloride → HCID 18654021, compound

HRID 374937Notes

Reaction equation

[CH3:1][O:2][C@:3]1([C:10]2[S:14][C:13]([S:15][C:16]3[CH:21]=[CH:20][C:19]([C:22](=O)[CH3:23])=[CH:18][CH:17]=3)=[N:12][CH:11]=2)[CH2:8][CH2:7][O:6][C@@H:5]([CH3:9])[CH2:4]1.Cl.[NH2:26][OH:27]>>[CH3:1][O:2][C@:3]1([C:10]2[S:14][C:13]([S:15][C:16]3[CH:21]=[CH:20][C:19](/[C:22](=[N:26]/[OH:27])/[CH3:23])=[CH:18][CH:17]=3)=[N:12][CH:11]=2)[CH2:8][CH2:7][O:6][C@@H:5]([CH3:9])[CH2:4]1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 57143913HCID 57143913, compound

Product 1

HCID 18654021HCID 18654021, compoundYield 84%

Procedure

Using an analogous procedure to that described in Example 15, 4'-{5-[(2S,4R)-4-methoxy-2-methyltetrahydropyran-4-yl]thiazol-2-ylthio}acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-{5-[(2S,4R)-4-methoxy-2-methyltetrahydropyran-4-yl]thiazol-2-ylthio}acetophenone oxime in 84% yield as a foam.

Sources & evidence

ORD record: ord-f29fac1cc3f94996a2451165d5eed885
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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