Hydroxyamine hydrochloride → HCID 18654050, compound

HRID 374939Notes

Reaction equation

[CH3:1][O:2][C:3]1([C:9]2[S:13][C:12]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([C:22](=O)[CH3:23])=[CH:18][CH:17]=3)=[N:11][CH:10]=2)[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.Cl.[NH2:26][OH:27]>>[CH3:1][O:2][C:3]1([C:9]2[S:13][C:12]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19](/[C:22](=[N:26]/[OH:27])/[CH3:23])=[CH:18][CH:17]=3)=[N:11][CH:10]=2)[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996152HCID 18996152, compound

Product 1

HCID 18654050HCID 18654050, compoundYield 57%

Procedure

Using an analogous procedure to that described in Example 15, 4'-[5-(4-methoxytetrahydropyran-4-yl)thiazol-2-yloxymethyl]acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-[5-(4-methoxytetrahydropyran-4-yl)thiazol-2-yloxymethyl]acetophenone oxime in 57% yield, m.p. 107°-109° C.;

Sources & evidence

ORD record: ord-b1a29a40a1ed46bdacb7415f2fc2a112
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

Loading…