Hydroxyamine hydrochloride → HCID 86748014, compound

HRID 374942Notes

Reaction equation

[CH3:1][C:2]([C:4]1[CH:5]=[N:6][C:7]([S:10]([C:13]2[CH:18]=[C:17]([F:19])[CH:16]=[C:15]([C:20]3([O:26][CH3:27])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[CH:14]=2)(=[O:12])=[O:11])=[CH:8][CH:9]=1)=O.Cl.[NH2:29][OH:30]>>[CH3:1][C:2](=[N:29][OH:30])[C:4]1[CH:5]=[N:6][C:7]([S:10]([C:13]2[CH:18]=[C:17]([F:19])[CH:16]=[C:15]([C:20]3([O:26][CH3:27])[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)[CH:14]=2)(=[O:11])=[O:12])=[CH:8][CH:9]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996284HCID 18996284, compound

Product 1

HCID 86748014HCID 86748014, compoundYield 96%

Procedure

Using an analogous procedure to that described in Example 50, 6-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylsulphonyl]pyrid-3-yl methyl ketone was reacted with hydroxylamine hydrochloride to give 6-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylsulphonyl]pyrid-3-yl methyl ketone oxime in 96% yield.

Sources & evidence

ORD record: ord-b16f32b94c7f48528fb54a285727fb97
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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