Hydroxyamine hydrochloride → HCID 10338763, compound

HRID 374944Notes

Reaction equation

[CH3:1][C:2]1([CH3:23])[O:6][C@:5]([C:8]2[CH:9]=[C:10]([S:13][C:14]3[CH:19]=[CH:18][C:17]([C:20](=O)[CH3:21])=[CH:16][CH:15]=3)[S:11][CH:12]=2)([CH3:7])[CH2:4][O:3]1.Cl.[NH2:25][OH:26]>>[CH3:1][C:2]1([CH3:23])[O:6][C@:5]([C:8]2[CH:9]=[C:10]([S:13][C:14]3[CH:19]=[CH:18][C:17](/[C:20](=[N:25]/[OH:26])/[CH3:21])=[CH:16][CH:15]=3)[S:11][CH:12]=2)([CH3:7])[CH2:4][O:3]1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 57312065HCID 57312065, compound

Product 1

HCID 10338763HCID 10338763, compoundYield 95%

Procedure

Using an analogous procedure to that described in Example 68, 4'-{4-[(4S)-2,2,4-trimethyl-1,3-dioxolan-4-yl]thien-2-ylthio}acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-{4-[(4S)-2,2,4-trimethyl-1,3-dioxolan-4-yl]thien-2-ylthio}acetophenone oxime in 95% yield as a gum.

Sources & evidence

ORD record: ord-be67f36205904adeab603d6859e91f8f
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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