反应详情

A mixture of one of these anthranils (1 part) and a tert-alkanol (1.1 to 1.2 parts) is warmed to effect solution, then is cooled in an ice-water bath while 70% perchloric acid or 60% hexafluorophosphoric acid (2 parts) is added at a rate which maintained the internal reaction temperature ≤35° C. After addition, the reaction mixture is stirred with ice-water cooling while the precipitate formed over about 30 minutes. This is slurried in ether and the salts are collected by filtration, washed with dry ether, and dried under vacuum to give the N-tert-alkyl anthranilium perchlorate or hexafluorophosphate salt as pale yellow solids in high yields.

1. additionis added at a rate which
2. temperaturemaintained the internal reaction temperature ≤35° C
3. additionAfter addition
4. customformed over about 30 minutes
5. filtrationthe salts are collected by filtration
6. washwashed with dry ether
7. customdried under vacuum