反应详情

N-Chlorosuccinimide (2.4 parts) is added to a solution of the primary benzamide (from method D or E) in dry acetonitrile, and the mixture is refluxed for 1 hour. This is partitioned between ether and aqueous Na2S2O3 and the organic layer is washed with 10% NaOH followed with brine, dried (MgSO4), filtered through silica gel, and concentrated to give the crude 5-chlorobenzamide.

1. temperaturethe mixture is refluxed for 1 hour
2. customThis is partitioned between ether and aqueous Na2S2O3
3. washthe organic layer is washed with 10% NaOH
4. dry with materialdried (MgSO4)
5. filtrationfiltered through silica gel
6. concentrationconcentrated