Hydrazine hydrate (1:1) → HCID 135991676, compound

HRID 37504Notes

Reaction equation

HRID 37504 reaction equation
[NH2:1][C:2]1[C:3]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[N:4][C:5]([N:18]2[CH:22]=[N:21][N:20]=[N:19]2)=[C:6]([C:13](OCC)=[O:14])[C:7]=1[C:8](OCC)=[O:9].O.[NH2:30][NH2:31]>C(O)C>[NH2:1][C:2]1[C:7]2[C:8](=[O:9])[NH:31][NH:30][C:13](=[O:14])[C:6]=2[C:5]([N:18]2[CH:22]=[N:21][N:20]=[N:19]2)=[N:4][C:3]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 152897023-Amino-4,5-diethoxycarbonyl-2-phenyl-6-(tetrazol-1-yl)pyridine

Product 1

HCID 135991676HCID 135991676, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

In 2 ml of ethanol was dissolved 0.172 g of 3-amino-4,5-diethoxycarbonyl-2-phenyl-6-(tetrazol-1-yl)pyridine, whereto 1 ml of hydrazine monohydrate was added. The mixture was reacted at 90° C. for 2 hours. After 15 ml of ethanol was added, the mixture was cooled. The precipitate was collected by filtration and washed with ethanol. The thus-obtained precipitate was dissolved in 20 ml of hot water, and 0.7 ml of acetic acid was added. The mixture was cooled, and the resulting precipitate was collected by filtration, washed and dried, to give 0.11 g of the title compound as yellow crystals.

Workup

  1. additionwas added
  2. customThe mixture was reacted at 90° C. for 2 hours
  3. temperaturethe mixture was cooled
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with ethanol
  6. dissolutionThe thus-obtained precipitate was dissolved in 20 ml of hot water
  7. addition0.7 ml of acetic acid was added
  8. temperatureThe mixture was cooled
  9. filtrationthe resulting precipitate was collected by filtration
  10. washwashed
  11. customdried

Sources & evidence

ORD record
ord-5cc06a6c7753457e9a2acd001ae0f521
Source dataset
uspto-grants-1995_05
Patent number
US05420275

Reaction notes

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