O-Xylene → HCID 18994049, compound

HRID 375049Notes

Reaction equation

HRID 375049 reaction equation
O.[C:2]1([C:8]([CH:10]=[O:11])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=1[CH3:19]>ClC(Cl)C.[Ti](Cl)(Cl)(Cl)Cl>[CH3:12][C:13]1[CH:14]=[C:15]([CH:16]=[CH:17][C:18]=1[CH3:19])[CH:10]([OH:11])[C:8](=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 7237O-XyleneHCID 12215922Glyoxal, phenyl-, hydrate

Product 1

HCID 18994049HCID 18994049, compound

Reagents, catalysts & solvents 2

HCID 24193Titanium TetrachlorideCatalystHCID 63651,1-DichloroethaneSolvent

Procedure

Phenylglyoxal monohydrate (304 mg, 2 mM) and o-xylene (0.49 ml, 4 mM) were dissolved in dichloroethane (4 ml), titanium tetrachloride (0.33 ml, 3 mM) was added, and reacted at room temperature for 20 minutes. Using the same procedure as in Example 1, 3',4'-dimethylbenzoin was obtained as crystal (258.7 mg, 54.0% yield).

Workup

  1. customreacted at room temperature for 20 minutes

Sources & evidence

ORD record
ord-d29665217b414af3970d1f48cb987e0e
Source dataset
uspto-grants-1996_01
Patent number
US05484689

Reaction notes

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