1,4-Dimethoxybenzene → HCID 18994059, compound

HRID 375051Notes

Reaction equation

HRID 375051 reaction equation
O.[C:2]1([C:8]([CH:10]=[O:11])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1>ClC(Cl)C.[Ti](Cl)(Cl)(Cl)Cl>[O:13]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[CH:10]([OH:11])[C:8](=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH3:12]

Participants

5

Reactant 2

HCID 90161,4-DimethoxybenzeneHCID 12215922Glyoxal, phenyl-, hydrate

Product 1

HCID 18994059HCID 18994059, compound

Reagents, catalysts & solvents 2

HCID 24193Titanium TetrachlorideCatalystHCID 63651,1-DichloroethaneSolvent

Procedure

Phenylglyoxal monohydrate (152 mg, 1 mM) and p-dimethoxybenzene (0.21 ml, 1.5 mM) were dissolved in dichloroethane (2 ml), titanium tetrachloride (0.33 ml, 3 mM) was added, and reacted at room temperature for 4 hours. Using the same procedure as in Example 1, 2',5'-dimethoxylbenzoin was obtained as an oil (219.4 mg, 79.2% yield).

Workup

  1. customreacted at room temperature for 4 hours

Sources & evidence

ORD record
ord-0df4ea03fddd4bd1be57cebf5df29192
Source dataset
uspto-grants-1996_01
Patent number
US05484689

Reaction notes

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