Hydrochloric Acid → HCID 54707634, compound

HRID 375084Notes

Reaction equation

HRID 375084 reaction equation
[CH:1]1[C:2]2[C:17](=[O:18])[C:16]([C:19]([OH:21])=[O:20])=[CH:15][N:14]([CH:22]3[CH2:24][CH2:23]3)[C:3]=2[CH:4]=[C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[C:6]=1[F:7].[Cl-].[Na+].[OH-:27].[Na+].Cl.[OH2:30]>>[CH2:23]1[CH:22]([N:14]2[C:3]3[C:2](=[CH:1][C:6]([F:7])=[C:5]([N:8]4[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]4)[CH:4]=3)[C:17](=[O:18])[C:16]([C:19]([OH:21])=[O:20])=[CH:15]2)[CH2:24]1.[CH2:17]1[CH:16]([C:19]([O-:21])=[O:20])[O:30][C:3](=[O:27])[CH2:2]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 2764Ciprofloxacin2×HCID 5234Sodium ChlorideHCID 14798Sodium Hydroxide

Product 1

HCID 54707634HCID 54707634, compound

Procedure

1.393 G (corresponding to 1 g of Ciprofloxacin) of each salt obtained in Examples 1-3 was dissolved in water to a 10 mL volume. An adequate amount of sodium chloride was added to the resulting solution to make it isotonic. The isotonic solution was diluted with saline to give a solution containing the salt as an active ingredient in the concentration of 1% (calculated in terms of Ciprofloxacin). The solution thus obtained was adjusted to pH 4.3 with a 2N sodium hydroxide or 2N hydrochloric acid solution.

Workup

  1. additionThe isotonic solution was diluted with saline
  2. customto give a solution
  3. customThe solution thus obtained

Sources & evidence

ORD record
ord-89bd688a58db461eaa479e3acf4e1b3f
Source dataset
uspto-grants-1996_01
Patent number
US05484785

Reaction notes

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