反应详情

Ethyl 6,6,6-trifluorohexylacetoacetate was added at -35° C. to a solution of sodium (50 moles, 1.15 g) in 150 ml ethanol and stirred for 15 minutes. N-Bromosuccinimide (50 mmoles, 8.9 g) was added. The solution was allowed to warm to room temperature and stirred for 2.5 hours. The mixture was poured into water. The intermediate was extracted with hexane. The solvent was removed. The oil was chromatographed over silica gel eluted with hexane to yield 13.6 g of ethyl 2-bromo-8,8,8-trifluorooctanoate. (MS).

1. stirringstirred for 2.5 hours
2. extractionThe intermediate was extracted with hexane
3. customThe solvent was removed
4. customThe oil was chromatographed over silica gel
5. washeluted with hexane