HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → Sodium Hydroxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 15222348 | HCID 15222348 | — |
| Reactant | HCID 178526856 | HCID 178526856 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Sodium Hydroxide | HCID 14798 | — |
| Product | HCID 15222349 | HCID 15222349 | — |
Reaction Steps
4-Nitroimidazole (43 mmoles, 4.86 g) was reacted with sodium hydride(43 moles, 1.72 g) and then ethyl 2-bromo-8,8,8-trifluorooctanoate (43 moles, 13.2 g) as in Example 1. The ester was hydrolyzed in 10 ml methanol and 30 ml 2N NaOH to yield a quantitative yield of 2-(4-nitro-1H-imidazol-1-yl)-8,8,8-trifluorooctanoic acid. (NMR)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05484780 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-e08675ddc11a432290e3343317f67b83 |
| Source note | uspto-grants-1996_01 |