HCID 18994418, compound → HCID 18994392, compound

HRID 375138Notes

Reaction equation

HRID 375138 reaction equation
[F:1][C:2]1[C:29]([F:30])=[C:28]([F:31])[C:27]([F:32])=[C:26]([F:33])[C:3]=1[CH:4]([C:6]1[CH:11]=[CH:10][C:9]([S:12][C:13]2[S:17][C:16]([C:18]3([O:24][CH3:25])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[CH:15][CH:14]=2)=[CH:8][CH:7]=1)[OH:5].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>>[F:33][C:26]1[C:27]([F:32])=[C:28]([F:31])[C:29]([F:30])=[C:2]([F:1])[C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([S:12][C:13]2[S:17][C:16]([C:18]3([O:24][CH3:25])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[CH:15][CH:14]=2)=[CH:8][CH:7]=1)=[O:5]

Participants

3

Reactant 2

HCID 18994418HCID 18994418, compoundHCID 178418287HCID 178418287, compound

Product 1

HCID 18994392HCID 18994392, compoundYield 75%

Procedure

Using the procedure described in Example 18, 4-[5-(4-(2,3,4,5,6-pentafluoro-alpha-hydroxybenzyl)phenylthio)thien-2-yl]-4-methoxytetrahydropyran was reacted with pyridinium chlorochromate to give 4-[5-(4-(2,3,4,5,6-pentafluorobenzoyl)phenylthio)thien-2-yl]-4-methoxytetrahydropyran in 75% yield, m.p. 93°-94° C.

Sources & evidence

ORD record
ord-ba5d7dce0719490497dd004babf9f680
Source dataset
uspto-grants-1996_01
Patent number
US05484805

Reaction notes

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