HCID 18994412, compound → HCID 18994400, compound

HRID 375139Notes

Reaction equation

HRID 375139 reaction equation
[OH:1][CH:2]([C:13]1[CH:18]=[CH:17][C:16]([S:19][C:20]2[S:24][C:23]([C:25]3([O:31][CH3:32])[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[CH:22][CH:21]=2)=[CH:15][CH:14]=1)[C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][CH:4]=1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>>[F:12][C:9]([F:10])([F:11])[C:6]1[CH:5]=[CH:4][C:3]([C:2]([C:13]2[CH:14]=[CH:15][C:16]([S:19][C:20]3[S:24][C:23]([C:25]4([O:31][CH3:32])[CH2:26][CH2:27][O:28][CH2:29][CH2:30]4)=[CH:22][CH:21]=3)=[CH:17][CH:18]=2)=[O:1])=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 18994412HCID 18994412, compoundHCID 178418287HCID 178418287, compound

Product 1

HCID 18994400HCID 18994400, compoundYield 75%

Procedure

Using the procedure described in Example 18, 4-[5-(4-(alphahydroxy-4-trifluoromethylbenzyl)phenylthio)thien-2-yl]-4-methoxytetrahydropyran was reacted with pyridinium chlorochromate to give 4-[5-(4-(4-trifluoromethylbenzoyl)phenylthio)thien-2-yl]-4-methoxytetrahydropyran in 75% yield, m.p. 86°-87° C.

Sources & evidence

ORD record
ord-5a64ea34986f45ecbe17b2431fe083d5
Source dataset
uspto-grants-1996_01
Patent number
US05484805

Reaction notes

Loading…