3-[4-(Trifluoromethyl)phenyl]prop-2-enoic acid → 155271-66-2

HRID 375350Notes

Reaction equation

HRID 375350 reaction equation
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[F:15][C:16]([F:29])([F:28])[C:17]1[CH:27]=[CH:26][C:20]([CH:21]=[CH:22][C:23](O)=O)=[CH:19][CH:18]=1>>[CH2:12]([N:4]1[C:3](=[O:14])[C:2]2[NH:1][C:23](/[CH:22]=[CH:21]/[C:20]3[CH:26]=[CH:27][C:17]([C:16]([F:15])([F:28])[F:29])=[CH:18][CH:19]=3)=[N:8][C:7]=2[N:6]([CH2:9][CH3:10])[C:5]1=[O:11])[CH3:13]

Participants

3

Reactant 2

HCID 749403-[4-(Trifluoromethyl)phenyl]prop-2-enoic acidHCID 45721335,6-Diamino-1,3-diethyluracil

Product 1

HCID 6448912155271-66-2Yield 49.3%

Procedure

Substantially the same procedure as in Example 7 was repeated using 2.20 g (11.2 mmol) of 5,6-diamino-1,3-diethyluracil and 2.66 g (12.3 mmol) of 4-trifluoromethylcinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 2.09 g (yield 49%) of Compound 136 as a white powder.

Workup

  1. customThen, the resultant crude crystals were recrystallized from dioxane/water

Sources & evidence

ORD record
ord-f2a73f427d90488781cb3a1cb4670fc6
Source dataset
uspto-grants-1996_01
Patent number
US05484920

Reaction notes

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