4-(Dimethylamino)cinnamic acid → 155271-92-4

HRID 375362Notes

Reaction equation

HRID 375362 reaction equation
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[CH3:15][N:16]([C:18]1[CH:28]=[CH:27][C:21]([CH:22]=[CH:23][C:24](O)=O)=[CH:20][CH:19]=1)[CH3:17]>>[CH3:15][N:16]([C:18]1[CH:28]=[CH:27][C:21](/[CH:22]=[CH:23]/[C:24]2[NH:1][C:2]3[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=3[N:8]=2)=[CH:20][CH:19]=1)[CH3:17]

Participants

3

Reactant 2

HCID 737784-(Dimethylamino)cinnamic acidHCID 45721335,6-Diamino-1,3-diethyluracil

Product 1

HCID 6448938155271-92-4Yield 52.1%

Procedure

Substantially the same procedure as in Example 7 was repeated using 3.00 g (15.1 mmol) of 5,6-diamino-1,3-diethyluracil and 3.30 g (17.3 mmol) of 4-(N,N-dimethylamino)cinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane to give 2.78 g (yield 52%) of Compound 162 as yellow needles.

Workup

  1. customThen, the resultant crude crystals were recrystallized from dioxane

Sources & evidence

ORD record
ord-9c032572f6674aab9435b7ae73bf2a99
Source dataset
uspto-grants-1996_01
Patent number
US05484920

Reaction notes

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