Piperazine → 2-Difluoroacetylimino-3(3-trifluoromethylphenyl)-5-methylthiazoline

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A solution of 2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline hydrochloride salt (1.47 g, 5.0 mmol), piperazine (0.64 g, 7.5 mmol) and triethylamine (1.52 g, 15.0 mmol) in diglyme (10 ml) charged in a reaction flask was reacted with tetrafluoroethylene, which was made to flow intothe flask (ca. 0.7 liter/hr), with vigorous stirring at 70° C. for 24 hours. After cooling to an ambient temperature, the reaction mixture was poured into ice-water, and extracted with diethyl ether. The diethyl ether layer was washed with water and then brine, and dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was subjected to silica gel column chromatography, which afforded 2-difluoroacetylimino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (1.01 g, 3.0 mmol, yield 60%).

Herkunft & Nachweise