HRID375436

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID23404

3-Thiopheneacetic acid

C6H6O2S

结构：COc1ccccc1[C@]1(O)CCC(c2ccccc2)(c2ccccc2)[C@H]2CNC[C@H]21.Cl

HCID70218598

未命名化合物

PRODUCTS

生成物

结构：COc1ccccc1[C@]1(O)CCC(c2ccccc2)(c2ccccc2)[C@H]2CN(C(=O)Cc3ccsc3)C[C@H]21

HCID57043806

未命名化合物

收率 55.2%

PROCEDURE

实验过程

By working in accordance with Example 4, starting from 0.8 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride and 0.34 g of 3-thienylacetic acid, 0.53 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(3-thienyl)acetyl]perhydroisoindol-4-ol is obtained in the form of white crystals which melt with decomposition at 106° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ff34104ce16846aca9f8af9ad2b98ba2
来源数据集: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05484804
来源说明: uspto-grants-1996_01

反应 SMILES

Cl.[C:2]1([C:8]2([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C@@H:16]3[C@@H:12]([CH2:13][NH:14][CH2:15]3)[C@@:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])([OH:17])[CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:32]1[CH:36]=[CH:35][C:34]([CH2:37][C:38](O)=[O:39])=[CH:33]1>>[C:26]1([C:8]2([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C@@H:16]3[C@@H:12]([CH2:13][N:14]([C:38](=[O:39])[CH2:37][C:34]4[CH:35]=[CH:36][S:32][CH:33]=4)[CH2:15]3)[C@@:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])([OH:17])[CH2:10][CH2:9]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1