HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Thiophenacetic acid → (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(3-thienyl)acetyl]perhydroisoindol-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Thiophenacetic acid | HCID 23404 | — |
| Reactant | (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride | HCID 70218598 | — |
| Product | (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(3-thienyl)acetyl]perhydroisoindol-4-ol | HCID 57043806 | 55.2% |
Reaction Steps
By working in accordance with Example 4, starting from 0.8 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride and 0.34 g of 3-thienylacetic acid, 0.53 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(3-thienyl)acetyl]perhydroisoindol-4-ol is obtained in the form of white crystals which melt with decomposition at 106° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05484804 |
| Source dataset | uspto-grants-1996_01 |
| ORD ID | ord-ff34104ce16846aca9f8af9ad2b98ba2 |
| Source note | uspto-grants-1996_01 |