Hydrochloric Acid → HCID 67745321, compound

HRID 375481Notes

Reaction equation

HRID 375481 reaction equation
[C:1]1([C:7]2([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:15]3[CH:11]([CH2:12][N:13](C(OC=C)=O)[CH2:14]3)[S:10](=[O:22])(=[O:21])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:29]>O1CCOCC1>[ClH:29].[C:23]1([C:7]2([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH:15]3[CH:11]([CH2:12][NH:13][CH2:14]3)[S:10](=[O:21])(=[O:22])[CH2:9][CH2:8]2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67745325HCID 67745325, compound

Product 1

HCID 67745321HCID 67745321, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

0.58 g of (4aRS,7aRS)-4,4-diphenyl-6-vinyloxycarbonyl perhydrothiopyrano[2,3-c]pyrrole 1,1-dioxide is treated with 25 cm3 of a 5.7N solution of hydrochloric acid in dry dioxane for 30 minutes while making lukewarm. The reaction solution is concentrated to dryness under reduced pressure (2.7 kPa) at 50° C. The residue is taken up in 15 cm3 of ethanol, the solution obtained is refluxed for 30 minutes and then concentrated to dryness. The solid obtained is washed with ethyl ether, drained and dried. 0.46 g of (4aRS,7aRS)-4,4-diphenylperhydrothiopyrano[2,3-c]pyrrole 1,1-dioxide hydrochloride is obtained in the form of a white solid.

Workup

  1. concentrationThe reaction solution is concentrated to dryness under reduced pressure (2.7 kPa) at 50° C
  2. customthe solution obtained
  3. temperatureis refluxed for 30 minutes
  4. concentrationconcentrated to dryness
  5. customThe solid obtained
  6. washis washed with ethyl ether
  7. customdried

Sources & evidence

ORD record
ord-1d76608e6197414eb66bcb26ed85d86b
Source dataset
uspto-grants-1996_01
Patent number
US05484942

Reaction notes

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